Direct Counting Analysis on Network Generated by Discrete Dynamics

A detail study on the In-degree Distribution (ID) of Cellular Automata is obtained by exact enumeration. The results indicate large deviation from multiscaling and classification according to ID are discussed. We further augment the transfer matrix as such the distributions for more complicated rules are obtained. Dependence of In-degree Distribution on the lattice size have also been found for some rules including R50 and R77.Comment: 8 pages, 11 figure

Cellular Ability to Sense Spatial Gradients in the Presence of Multiple Competitive Ligands

Many eukaryotic and prokaryotic cells can exhibit remarkable sensing ability under small gradient of chemical compound. In this study, we approach this phenomenon by considering the contribution of multiple ligands to the chemical kinetics within Michaelis-Menten model. This work was inspired by the recent theoretical findings from Bo Hu et al. [Phys. Rev. Lett. 105, 048104 (2010)], our treatment with practical binding energies and chemical potential provides the results which are consistent with experimental observations.Comment: 5 pages, 4 figure

Vibration characteristics and modal analysis of a grinding machine

The machine industry has undergone several developments in the past years, and reducing the cost and time required for machine designing is important. In this study, the vibration characteristics of a precision grinding machine were obtained through experimental modal analysis and finite element analysis. The experimental modal analysis employed single point excitation, and the equipment used to determine the frequency response of the grinding machine comprised a hammer, an accelerometer, and a spectrum analyzer. In addition, the resonance frequency, damping factor, and modal shape of the grinding machine were determined. The natural frequency, modal shape, and interface stiffness were determined through finite element analysis. Finally, the theoretical model and the experimental modal analysis models were compared, and get closer to the actual situation of a model to conduct several times analysis. Thus, this paper presents a reliable and convenient method to study the characteristics of machine tools; this method can reduce unnecessary costs and find structural weaknesses in machine designs for improvement

Congestion Control for Machine-Type Communications in LTE-A Networks

Collecting data from a tremendous amount of Internet-of-Things (IoT) devices for next generation networks is a big challenge. A large number of devices may lead to severe congestion in Radio Access Network (RAN) and Core Network (CN). 3GPP has specified several mechanisms to handle the congestion caused by massive amounts of devices. However, detailed settings and strategies of them are not defined in the standards and are left for operators. In this paper, we propose two congestion control algorithms which efficiently reduce the congestion. Simulation results demonstrate that the proposed algorithms can achieve 20~40% improvement regarding accept ratio, overload degree and waiting time compared with those in LTE-A

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.

Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1. We recently found that CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex. It is currently unclear how quality control and protein degradation systems coordinate with each other to process the biosynthesis of CLC-1. Herein we aim to ascertain the molecular nature of the protein quality control system for CLC-1. We identified three CLC-1-interacting proteins that are well-known heat shock protein 90 (Hsp90)-associated co-chaperones: FK506-binding protein 8 (FKBP8), activator of Hsp90 ATPase homolog 1 (Aha1), and Hsp70/Hsp90 organizing protein (HOP). These co-chaperones promote both the protein level and the functional expression of CLC-1 wild-type and A531V mutant. CLC-1 biosynthesis is also facilitated by the molecular chaperones Hsc70 and Hsp90β. The protein stability of CLC-1 is notably increased by FKBP8 and the Hsp90β inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) that substantially suppresses cullin 4 expression. We further confirmed that cullin 4 may interact with Hsp90β and FKBP8. Our data are consistent with the idea that FKBP8 and Hsp90β play an essential role in the late phase of CLC-1 quality control by dynamically coordinating protein folding and degradation